Significant Aggravation [National Vaccine Injury Compensation Program] Law and Legal Definition

According to 42 USCS § 300aa-33 [Title 42. The Public Health and Welfare; Chapter 6a. The Public Health Service; Vaccines; National Vaccine Injury Compensation Program; General Provisions], significant aggravation means “any change for the worse in a preexisting condition which results in markedly greater disability, pain, or illness accompanied by substantial deterioration of health.”